Multi-parameter Sensing System for Single Cell Studies
Çağdaş Varel, Karl F. Böhringer
Conventional biological measurements typically take averages over cell populations and ignore the heterogeneity among cells, which is important for cancer research to examine cell damage and cell proliferation. This project aims to fabricate a non-destructive single cell monitoring micro device added to a conventional fluorescence microscope. The device monitors oxygen consumption rate, pH change and temperature of a single cell, which give information about cell metabolism, metabolic rate and cell growth rate.
In the long term, developed sensor deposition method can be used for deposition of various sensors and protein arrays.
Figure 1: Glass chamber for cell monitoring