Anupama V. Govindarajan
Department of Electrical Engineering
University of Washington
253I EE/CSE Building
Seattle, WA 98195-2500, USA
Anupama’s thesis work includes the design, fabrication and testing of an implantable BioMEMS sensor capable of intracellular neuronal recording. This work gives the first evidence of intracellular interrogation by an integrated implantable MEMS sensor. The sensor comprised of a high aspect ratio, sub-µm tip needle electrode integrated with a flexible polyimide-aluminum-polyimide interconnect. The success of this prototype is a major step toward self contained implantable devices suited for intracellular neuronal recording from freely behaving animals. This work involves significant inter-departmental collaboration.
She has investigated biomaterials developed at The University of Washington Engineered Biomaterials Center (UWEB) as possible coatings for implantable neural electrodes. Application of these biomaterial coatings can be easily integrated with standard microfabrication processes.
The last part of her thesis is in collaboration with the Indian Institute of Technology (IIT Bombay). Here she has developed a technique for vapor-liquid-solid growth of needle arrays by hot-wire-chemical-vapor-deposition (HWCVD) at low substrate temperature. This low temperature growth technique has the potential for integration of CMOS circuitry and biomaterials like polyimide with neural electrodes. Needle arrays grown by this technique can potentially enable high throughput neural recordings. She has independently initiated and developed research collaborations between IIT Bombay and University of Washington (2007-present).
More about her research here.
• Ph.D. thesis work won the first prize for the most innovative research at the Pacific Northwest Workshop on Neural Engineering – Oct 9-11, 2008, Redmond WA.
• National Institutes of Health - University of Washington Engineered Biomaterials Training Grant Fellowship 2006-2008.
• Spirit of the Community Award 2004 – Electrical Engineering, University of Washington.
A.V.Govindarajan, T.C.Chen, R.C.Wyeth, A.O.D.Willows and K.F.Böhringer, "Intracellular Neuronal Recording With Flexible Micro-Machined Probe Implants." Solid State Sensor, Actuator, and Microsystems Workshop (Hilton Head'04), Hilton Head Island, SC, June 6-10, 2004. pp172-175.
A.V.Govindarajan, M.Joshi, S.Mukherji, R.Rao and K.F.Böhringer, "Engineering the Hydrophobicity Oxide Surfaces by Controlling the Dehydration Temperature of Silanization", European Materials Research Society Symposium on Protective Coatings and Thin Films (EMRS), Strasbourg, France, May 28 - June 1, 2007.
A.V.Govindarajan, S.Paluri, A.Sharma, R.Rao and K.F. Bohringer, “Selective Vapor Liquid Solid Growth of Needle Arrays by Hot Wire Chemical Vapor Deposition with Low Substrate Temperature”, accepted at The fifteenth International Conference on Solid State Sensors, Actuators and Microsystems (Transducers’09), Denver, Colorado, June 21-25 2009 .